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KMID : 0878220230350010014
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Journal of Sasang Constitutional Medicine
2023 Volume.35 No. 1 p.14 ~ p.24
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Development of the Animal Model with Spleen Deficiency and Observation of Changes in heat and cold
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Kwak Jin-Young
Yang Won-Kyung
Kim Seung-Hyung
Jung In-Chul
Park Yang-Chun
Ahn Taek-Won
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Abstract
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Objectives This study was conducted to observe physiological changes when the function of spleen was extremely deteriorated, and to make an animal model with spleen deficiency.
Methods The Normal group (Nr group) was not administered with Senna Folium extract. The SFE group(Senna Folium extract group) was administered with Senna Folium extract every day for the first 2 weeks and then every other day for another week. And the SFE_G group(Senna Folium extract_Ginseng group) was also administered with Senna Folium for 3weeks like the SFE group and fed with ginseng in the third week.
Results The score of spleen deficiency was significantly higher in SFE group than in the Nr group and significantly lower in the SFE_G group than in the SFE group. The total weight gain was significantly lower in the SFE group than in the Nr group, and the average daily weight gain was significantly lower in the SFE group than in the Nr group. The difference in stool weight before and after the process of drying was significantly higher in the SFE group than in the Nr group, and significantly lower in the SFE-G group than the SFE group. There was no significant difference in the outcomes related to cold and heat among the three groups.
Conclusions Through this study, the animal model with spleen deficiency was developed to prepare a stepping stone for animal tests to verify the efficacy and safety of constitutional prescriptions.
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KEYWORD
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Spleen dificiency, Soeum-in, animal model, Sasang Constitutional Medicine, heat and cold
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